Reaction Details |
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Target | P-selectin glycoprotein ligand 1 |
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Ligand | BDBM50324664 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649756 (CHEMBL1219454) |
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IC50 | 250000±n/a nM |
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Citation | Huang, A; Moretto, A; Janz, K; Lowe, M; Bedard, PW; Tam, S; Di, L; Clerin, V; Sushkova, N; Tchernychev, B; Tsao, DH; Keith, JC; Shaw, GD; Schaub, RG; Wang, Q; Kaila, N Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. J Med Chem53:6003-17 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P-selectin glycoprotein ligand 1 |
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Name: | P-selectin glycoprotein ligand 1 |
Synonyms: | P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 43174.76 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_649756 |
Residue: | 412 |
Sequence: | MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
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BDBM50324664 |
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n/a |
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Name | BDBM50324664 |
Synonyms: | 3-Hydroxy-2-(1-phenylcyclopropyl)-7,8,9,10-tetrahydrobenzo-[h]quinoline-4-carboxylic Acid | CHEMBL1215806 |
Type | Small organic molecule |
Emp. Form. | C23H21NO3 |
Mol. Mass. | 359.4177 |
SMILES | OC(=O)c1c(O)c(nc2c3CCCCc3ccc12)C1(CC1)c1ccccc1 |
Structure |
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