| Reaction Details |
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 | Report a problem with these data |
| Target | P-selectin glycoprotein ligand 1 |
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| Ligand | BDBM50201977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_649756 (CHEMBL1219454) |
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| IC50 | 413000±n/a nM |
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| Citation |  Huang, A; Moretto, A; Janz, K; Lowe, M; Bedard, PW; Tam, S; Di, L; Clerin, V; Sushkova, N; Tchernychev, B; Tsao, DH; Keith, JC; Shaw, GD; Schaub, RG; Wang, Q; Kaila, N Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury. J Med Chem53:6003-17 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P-selectin glycoprotein ligand 1 |
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| Name: | P-selectin glycoprotein ligand 1 |
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| Synonyms: | P-selectin glycoprotein ligand 1 | P-selectin/P-selectin glycoprotein ligand 1 | SELPLG | SELPL_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43174.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_649756 |
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| Residue: | 412 |
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| Sequence: | MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
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| BDBM50201977 |
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| n/a |
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| Name | BDBM50201977 |
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| Synonyms: | 2-benzyl-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid | CHEMBL384767 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19NO3 |
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| Mol. Mass. | 333.3805 |
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| SMILES | OC(=O)c1c(O)c(Cc2ccccc2)nc2c3CCCCc3ccc12 |
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| Structure | 
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