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TargetMonocarboxylate transporter 1
LigandBDBM22025
Substrate/Competitorn/a
Meas. Tech.ChEMBL_653483
Ki 6.3±n/a nM
Citation Murray CMHutchinson RBantick JRBelfield GPBenjamin ADBrazma DBundick RVCook IDCraggs RIEdwards SEvans LRHarrison RHolness EJackson APJackson CGKingston LPPerry MWRoss ARRugman PASidhu SSSullivan MTaylor-Fishwick DAWalker PCWhitehead YMWilkinson DJWright ADonald DK Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol 1:371-6 (2005) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Monocarboxylate transporter 1
Name:Monocarboxylate transporter 1
Synonyms:MCT 1 | Solute carrier family 16 member 1
Type:PROTEIN
Mol. Mass.:53956.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1451367
Residue:500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22025
n/a
NameBDBM22025
Synonyms:5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-indol-3-ylmethyl)-3-methyl-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 33
TypeSmall organic molecule
Emp. Form.C25H28N4O4S
Mol. Mass.480.579
SMILESCC(C)Cn1c2sc(Cc3c[nH]c4ccccc34)c(C(=O)N3CC[C@@H](O)C3)c2c(=O)n(C)c1=O |r|
Structure
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