| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50324853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_651475 (CHEMBL1227592) |
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| Ki | 12±n/a nM |
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| Citation |  Beattie, D; Bradley, M; Brearley, A; Charlton, SJ; Cuenoud, BM; Fairhurst, RA; Gedeck, P; Gosling, M; Janus, D; Jones, D; Lewis, C; McCarthy, C; Oakman, H; Stringer, R; Taylor, RJ; Tuffnell, A A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators. Bioorg Med Chem Lett20:5302-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50324853 |
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| n/a |
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| Name | BDBM50324853 |
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| Synonyms: | (R)-7-(2-(cycloheptylamino)-1-hydroxyethyl)-4-hydroxybenzo[d]thiazol-2(3H)-one | CHEMBL1221679 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N2O3S |
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| Mol. Mass. | 322.422 |
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| SMILES | O[C@@H](CNC1CCCCCC1)c1ccc(O)c2[nH]c(=O)sc12 |r| |
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| Structure | 
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