Reaction Details |
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Target | Caspase-1 |
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Ligand | BDBM10355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_651546 (CHEMBL1227798) |
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Ki | 9±n/a nM |
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Citation | Galatsis, P; Caprathe, B; Gilmore, J; Thomas, A; Linn, K; Sheehan, S; Harter, W; Kostlan, C; Lunney, E; Stankovic, C; Rubin, J; Brady, K; Allen, H; Talanian, R Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett20:5184-90 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-1 |
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Name: | Caspase-1 |
Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
Type: | PROTEIN |
Mol. Mass.: | 45636.44 |
Organism: | Mus musculus |
Description: | ChEMBL_651546 |
Residue: | 402 |
Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
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BDBM10355 |
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n/a |
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Name | BDBM10355 |
Synonyms: | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid | Ac-YVAD-CHO | CHEMBL37630 |
Type | Small organic molecule |
Emp. Form. | C23H32N4O8 |
Mol. Mass. | 492.5222 |
SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O |r| |
Structure |
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