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TargetDisintegrin and metalloproteinase domain-containing protein 17
LigandBDBM50325003
Substrate/Competitorn/a
Meas. Tech.ChEMBL_651587 (CHEMBL1227970)
Ki 0.1±n/a nM
Citation Yu, WTong, LKim, SHWong, MKChen, LYang, DYShankar, BBLavey, BJZhou, GKosinski, ARizvi, RLi, DFeltz, RJPiwinski, JJRosner, KEShih, NYSiddiqui, MAGuo, ZOrth, PShah, HSun, JUmland, SLundell, DJNiu, XKozlowski, JA Biaryl substituted hydantoin compounds as TACE inhibitors. Bioorg Med Chem Lett20:5286-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Disintegrin and metalloproteinase domain-containing protein 17
Name:Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE)
Type:Enzyme
Mol. Mass.:93007.89
Organism:Homo sapiens (Human)
Description:
Residue:824
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50325003
n/a
NameBDBM50325003
Synonyms:(R)-5-(4-(5-chloro-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)imidazolidine-2,4-dione | CHEMBL1222942
TypeSmall organic molecule
Emp. Form.C23H16ClFN4O4
Mol. Mass.466.849
SMILESFc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(cc3)-c3c[nH]c(=O)c(Cl)c3)C(=O)c2c1 |r|
Structure
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