Reaction Details |
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Target | C-C chemokine receptor type 5 |
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Ligand | BDBM50321682 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_651986 (CHEMBL1227659) |
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IC50 | 2.9±n/a nM |
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Citation | Li, B; Jones, ED; Zhou, E; Chen, L; Baylis, DC; Yu, S; Wang, M; He, X; Coates, JA; Rhodes, DI; Pei, G; Deadman, JJ; Xie, X; Ma, D Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents. Bioorg Med Chem Lett20:5334-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 5 |
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Name: | C-C chemokine receptor type 5 |
Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
Type: | Enzyme |
Mol. Mass.: | 40540.21 |
Organism: | Homo sapiens (Human) |
Description: | P51681 |
Residue: | 352 |
Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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BDBM50321682 |
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n/a |
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Name | BDBM50321682 |
Synonyms: | CHEMBL1172035 | nifeviroc |
Type | Small organic molecule |
Emp. Form. | C33H42N4O6 |
Mol. Mass. | 590.7098 |
SMILES | O[C@@]1(CN(C[C@@H]1CN1CCC(CC1)N(CC=C)C(=O)OCc1ccc(cc1)[N+]([O-])=O)C(=O)C1CCCC1)c1ccccc1 |r| |
Structure |
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