| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50325722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652569 (CHEMBL1225772) |
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| IC50 | 17±n/a nM |
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| Citation |  Merritt, JR; James, R; Paradkar, VM; Zhang, C; Liu, R; Liu, J; Jacob, B; Chiriac, C; Ohlmeyer, MJ; Quadros, E; Wines, P; Postelnek, J; Hicks, CM; Chen, W; Kimble, EF; O'Brien, L; White, N; Desai, H; Appell, KC; Webb, ML Novel pyrrolidine heterocycles as CCR1 antagonists. Bioorg Med Chem Lett20:5477-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50325722 |
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| n/a |
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| Name | BDBM50325722 |
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| Synonyms: | (R)-2-(4-(4-chlorobenzyl)-4H-1,2,4-triazol-3-yl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide | CHEMBL1224188 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19ClF3N5O |
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| Mol. Mass. | 449.857 |
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| SMILES | FC(F)(F)c1ccc(NC(=O)N2CCC[C@@H]2c2nncn2Cc2ccc(Cl)cc2)cc1 |r| |
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| Structure | 
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