| Reaction Details |
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 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
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| Ligand | BDBM50325727 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652596 (CHEMBL1225799) |
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| EC50 | 1700±n/a nM |
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| Citation |  Harrington, PE; St Jean, DJ; Clarine, J; Coulter, TS; Croghan, M; Davenport, A; Davis, J; Ghiron, C; Hutchinson, J; Kelly, MG; Lott, F; Lu, JY; Martin, D; Morony, S; Poon, SF; Portero-Larragueta, E; Reagan, JD; Regal, KA; Tasker, A; Wang, M; Yang, Y; Yao, G; Zeng, Q; Henley, C; Fotsch, C The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core. Bioorg Med Chem Lett20:5544-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Extracellular calcium-sensing receptor |
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| Name: | Extracellular calcium-sensing receptor |
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| Synonyms: | CASR | CASR_HUMAN | CaR | Calcium sensing receptor | Calcium-sensing receptor (CaSR) | Extracellular calcium-sensing receptor | GPRC2A | PCAR1 | Parathyroid Cell calcium-sensing receptor | Parathyroid cell calcium-sensing receptor 1 | Synonyms=GPRC2A | hCasR |
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| Type: | Protein |
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| Mol. Mass.: | 120663.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41180 |
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| Residue: | 1078 |
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| Sequence: | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
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| BDBM50325727 |
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| n/a |
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| Name | BDBM50325727 |
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| Synonyms: | (R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methoxyphenyl)ethanamine | CHEMBL1224192 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClNO |
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| Mol. Mass. | 351.869 |
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| SMILES | COc1cccc(c1)[C@@H](C)NCc1cccc(c1)-c1ccccc1Cl |r| |
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| Structure | 
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