| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50325879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652678 (CHEMBL1225881) |
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| IC50 | 104±n/a nM |
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| Citation |  Letourneau, JJ; Jokiel, P; Olson, J; Riviello, CM; Ho, KK; McAleer, L; Yang, J; Swanson, RN; Baker, J; Cowley, P; Edwards, D; Ward, N; Ohlmeyer, MH; Webb, ML Identification and hit-to-lead optimization of a novel class of CB1 antagonists. Bioorg Med Chem Lett20:5449-53 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50325879 |
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| n/a |
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| Name | BDBM50325879 |
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| Synonyms: | CHEMBL1224370 | N-(3-fluorobenzyl)-1-((2'-methoxybiphenyl-3-yl)methyl)-1H-benzo[d]imidazole-6-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24FN3O2 |
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| Mol. Mass. | 465.5182 |
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| SMILES | COc1ccccc1-c1cccc(Cn2cnc3ccc(cc23)C(=O)NCc2cccc(F)c2)c1 |
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| Structure | 
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