| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50325888 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652678 (CHEMBL1225881) |
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| IC50 | 7±n/a nM |
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| Citation |  Letourneau, JJ; Jokiel, P; Olson, J; Riviello, CM; Ho, KK; McAleer, L; Yang, J; Swanson, RN; Baker, J; Cowley, P; Edwards, D; Ward, N; Ohlmeyer, MH; Webb, ML Identification and hit-to-lead optimization of a novel class of CB1 antagonists. Bioorg Med Chem Lett20:5449-53 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50325888 |
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| n/a |
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| Name | BDBM50325888 |
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| Synonyms: | CHEMBL1224534 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl)pyridin-2-yl)methyl)-1H-indol-6-yl)-3-hydroxy-2,2-dimethylpropanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N3O4 |
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| Mol. Mass. | 443.4944 |
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| SMILES | CC(C)(CO)C(=O)Nc1ccc2ccn(Cc3cccc(n3)-c3cccc4OCOc34)c2c1 |
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| Structure | 
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