| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50325924 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_654086 (CHEMBL1228892) |
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| EC50 | 140±n/a nM |
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| Citation |  Peters, JU; Kühne, H; Dehmlow, H; Grether, U; Conte, A; Hainzl, D; Hertel, C; Kratochwil, NA; Otteneder, M; Narquizian, R; Panousis, CG; Ricklin, F; Röver, S Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett20:5426-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41476.06 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_820675 |
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| Residue: | 360 |
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| Sequence: | MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSIC
YTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVIC
FLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
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| BDBM50325924 |
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| n/a |
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| Name | BDBM50325924 |
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| Synonyms: | 2-((3-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrimidin-4(3H)-one | CHEMBL1224219 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClN3O2 |
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| Mol. Mass. | 315.754 |
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| SMILES | Clc1cccc(CCOCc2nc3ncccc3c(=O)[nH]2)c1 |
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| Structure | 
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