| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50325899 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652724 (CHEMBL1225927) |
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| EC50 | 1700±n/a nM |
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| Citation |  Peters, JU; Kühne, H; Dehmlow, H; Grether, U; Conte, A; Hainzl, D; Hertel, C; Kratochwil, NA; Otteneder, M; Narquizian, R; Panousis, CG; Ricklin, F; Röver, S Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett20:5426-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50325899 |
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| n/a |
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| Name | BDBM50325899 |
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| Synonyms: | 2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4(3H)-one | CHEMBL1223819 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H4F3N3O |
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| Mol. Mass. | 215.1321 |
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| SMILES | FC(F)(F)c1nc2ncccc2c(=O)[nH]1 |
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| Structure | 
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