Reaction Details |
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Target | Cyclin-dependent protein kinase PHO85/PHO85 cyclin PHO80/Phosphate system positive regulatory protein PHO81 |
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Ligand | BDBM50326018 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_654965 (CHEMBL1244009) |
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Ki | 19000±n/a nM |
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Citation | Lee, YS; Huang, K; Quiocho, FA; O'Shea, EK Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate. Nat Chem Biol4:25-32 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent protein kinase PHO85/PHO85 cyclin PHO80/Phosphate system positive regulatory protein PHO81 |
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Name: | Cyclin-dependent protein kinase PHO85/PHO85 cyclin PHO80/Phosphate system positive regulatory protein PHO81 |
Synonyms: | Cyclin-dependent protein kinase PHO85 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 654965 |
Components: | This complex has 1 components. |
Component 1 |
Name: | Cyclin-dependent protein kinase PHO85 |
Synonyms: | Cyclin-dependent protein kinase PHO85 | PHO85 | PHO85_YEAST | Pho80/Pho85 | SSG3 |
Type: | PROTEIN |
Mol. Mass.: | 34912.85 |
Organism: | Saccharomyces cerevisiae |
Description: | ChEMBL_563813 |
Residue: | 305 |
Sequence: | MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL
KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG
LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL
MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP
KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY
YHHAS
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Component 2 |
Name: | Phosphate system positive regulatory protein PHO81 |
Synonyms: | CDK inhibitor PHO81 | PHO81 | PHO81_YEAST |
Type: | PROTEIN |
Mol. Mass.: | 134012.60 |
Organism: | Saccharomyces cerevisiae |
Description: | ChEMBL_654961 |
Residue: | 1178 |
Sequence: | MKFGKYLEARQLELAEYNSHFIDYKALKKLIKQLAIPTLKASSDLDLHLTLDDIDEKIIH
QRLQENKAAFFFKLERELEKVNGYYLARESDLRIKFNILHSKYKDYKINGKLNSNQATSF
KNLYAAFKKFQKDLRNLEQYVELNKTGFSKALKKWDKRSQSHDKDFYLATVVSIQPIFTR
DGPLKLNDETLHILLELNDIDNNNRRADIQSSTFTNDDDDDNNTSNNNKHNNNNNNNNNN
NNNNNNNNILHNNYELTTSKISENQLEHLFQASSSSLDMEMEIENWYKEILNIATVKDVQ
RKHALLRNFRETKIFTYLLQNSSESFHKNVFSLLKECLTTLFLLLVASPLDDNSLHIFYK
SNQDHIDLSYCDEDDQVFSRKNVFHEAASCPEKSRLFILDEALTTSKLSKETVQKLLNAQ
DIHSRVPLHYAAELGKLEFVHSLLITNLLEDVDPIDSDSKTPLVLAITNNHIDVVRDLLT
IGGANASPIEKPILDYSKNVISSTKVQFDPLNVACKFNNHDAAKLLLEIRSKQNADNAKN
KSSQHLCQPLFKKNSTGLCTLHIVAKIGGDPQLIQLLIRYGADPNEIDGFNKWTPIFYAV
RSGHSEVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQRPLNLPSAPLNEIN
SQSSTQRLNTIDLTPNDDKFDLDIQDSIPDFALPPPIIPLRKYGHNFLEKKIFIKLKLRP
GLESIKLTQDNGIIMSSSPGRITLSSNLPEIIPRNVILPVRSGEINNFCKDISETNDEED
DDEISEDHDDGEIIFQVDSIDDFSMDFEIFPSFGTRIIAKTTAMPFLFKKVAINSIATMN
LPLFDTRLNNIGSLTLDYQIIFPYPGNPLKIINYEPYWKSTGSDLMTSSKDGNFVTSSSL
NGSFISVLVCALNDETIVAAPKPYVEFKGTKILLNDLTKEQLEKVVDYDFGKIDGSFDEV
TLKQYLSSRVVPLRSLLEVIPGSAQLVIRVYFPTDKEIDTIPIKISPFININQFIDKLLL
IIFEHERFLRHSGSGSMRQIVFSSCNWEACSILNWKQPNFPVLLQMKNLLRDSTTGKFVG
DTPNCLKELAVNPQKMSYLNTELINIHTMVQFAMNNNLLGVTLPYEVLKICPSLARIIKQ
NGLLLIASVGENDQIPADGGYSGIYYACELLFENNIDM
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Component 3 |
Name: | PHO85 cyclin PHO80 |
Synonyms: | AGS3 | Aminoglycoside antibiotic sensitivity protein 3 | PHO80 | PHO80_YEAST | Phosphate system cyclin PHO80 | TUP7 | VAC5 |
Type: | PROTEIN |
Mol. Mass.: | 33238.94 |
Organism: | Saccharomyces cerevisiae |
Description: | EBI_103488 |
Residue: | 293 |
Sequence: | MESTSGERSENIHEDQGIPKVILPADFNKCSRTDLVVLISRMLVSLIAINENSATKKSDD
QITLTRYHSKIPPNISIFNYFIRLTKFSSLEHCVLMTSLYYIDLLQTVYPDFTLNSLTAH
RFLLTATTVATKGLCDSFSTNAHYAKVGGVRCHELNILENDFLKRVNYRIIPRDHNITLC
SIEQKQKKFVIDKNALGSLDLDSYSYVNRPKSGYNVLDKYYRRIVQLVGSFNASPDKSRK
VDYVLPPNIDIVSESGSQTTQLKGSSSPNSHSSQKRYSEAKDAHIYNKRSKPD
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BDBM50326018 |
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n/a |
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Name | BDBM50326018 |
Synonyms: | (1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyldiphosphoric acid | CHEMBL1242023 |
Type | Small organic molecule |
Emp. Form. | C6H19O27P7 |
Mol. Mass. | 740.0152 |
SMILES | OP(O)(=O)O[C@@H]1[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(=O)OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O |r| |
Structure |
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