Ki Summary

Reaction Details

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Target

Phosphorylase kinase

Ligand

BDBM50326053

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_655520

900±n/a nM

Citation

Zarrinkar PP; Gunawardane RN; Cramer MD; Gardner MF; Brigham D; Belli B; Karaman MW; Pratz KW; Pallares G; Chao Q; Sprankle KG; Patel HK; Levis M; Armstrong RC; James J; Bhagwat SS AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-92 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Phosphorylase kinase

Name:

Phosphorylase kinase

Synonyms:

PHKG2 | Phosphorylase kinase gamma subunit 2

Type:

PROTEIN

Mol. Mass.:

46440.15

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774277

Residue:

406

Sequence:

MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG

BDBM50326053

n/a

Name

BDBM50326053

Synonyms:

CHEMBL608533 | PKC-412

Type

Small organic molecule

Emp. Form.

C35H30N4O4

Mol. Mass.

570.6371

SMILES

CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r|

Structure