| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase RIO3 |
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| Ligand | BDBM50300690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_655913 |
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| Kd | >10000±n/a nM |
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| Citation |  Zarrinkar PP; Gunawardane RN; Cramer MD; Gardner MF; Brigham D; Belli B; Karaman MW; Pratz KW; Pallares G; Chao Q; Sprankle KG; Patel HK; Levis M; Armstrong RC; James J; Bhagwat SS AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-92 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase RIO3 |
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| Name: | Serine/threonine-protein kinase RIO3 |
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| Synonyms: | RIOK3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59082.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774406 |
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| Residue: | 519 |
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| Sequence: | MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVA
VAEGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVH
PYEDSDSSEDEVDWQDTRDDPYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARME
NFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLL
MYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDSKVIPTECAIKVFKTTLNEFK
NRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMS
FIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVW
LIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEAD
FLAEIEALEKMNEDHVQKNGRKAASFLKDDGDPPLLYDE
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| BDBM50300690 |
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| n/a |
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| Name | BDBM50300690 |
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| Synonyms: | CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea | US9216997, Quizartinib (positive compound) |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N6O4S |
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| Mol. Mass. | 560.667 |
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| SMILES | CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 |
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| Structure | 
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