| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 4 |
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| Ligand | BDBM50326057 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_656729 (CHEMBL1245773) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Jenkinson, S; Thomson, M; McCoy, D; Edelstein, M; Danehower, S; Lawrence, W; Wheelan, P; Spaltenstein, A; Gudmundsson, K Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist. Antimicrob Agents Chemother54:817-24 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 4 |
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| Name: | C-X-C chemokine receptor type 4 |
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| Synonyms: | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4_MOUSE | Cmkar4 | Cxcr4 | Fusin | Lestr | Leukocyte-derived seven transmembrane domain receptor | PB-CKR | Pre-B-cell-derived chemokine receptor | SDF-1 receptor | Sdf1r | Stromal cell-derived factor 1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40435.89 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_656729 |
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| Residue: | 359 |
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| Sequence: | MEPISVSIYTSDNYSEEVGSGDYDSNKEPCFRDENVHFNRIFLPTIYFIIFLTGIVGNGL
VILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTV
NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDFIFADVS
QGDISQGDDRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQ
KRKALKTTVILILAFFACWLPYYVGISIDSFILLGVIKQGCDFESIVHKWISITEALAFF
HCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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| BDBM50326057 |
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| n/a |
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| Name | BDBM50326057 |
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| Synonyms: | ([5-(4-Methyl-1-piperazinyl)-2-({methyl[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]amino}methyl)imidazo[1,2-a]pyridin-3-yl]methanol) | CHEMBL1242210 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N6O |
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| Mol. Mass. | 420.5505 |
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| SMILES | CN(Cc1nc2cccc(N3CCN(C)CC3)n2c1CO)[C@H]1CCCc2cccnc12 |r| |
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| Structure | 
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