| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-7 |
|---|
| Ligand | BDBM10246 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_659716 (CHEMBL1246138) |
|---|
| IC50 | 59.1±n/a nM |
|---|
| Citation |  Newton, AS; Glória, PM; Gonçalves, LM; dos Santos, DJ; Moreira, R; Guedes, RC; Santos, MM Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem45:3858-63 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-7 |
|---|
| Name: | Caspase-7 |
|---|
| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34273.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55210 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
|
|
|
|---|
| BDBM10246 |
|---|
| n/a |
|---|
| Name | BDBM10246 |
|---|
| Synonyms: | (4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(3S)-3-acetamido-3-formamidopropanoic acid]butanoic acid | Ac-DEVD-CHO | CHEMBL417149 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30N4O11 |
|---|
| Mol. Mass. | 502.4724 |
|---|
| SMILES | CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
