| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50326285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_659951 (CHEMBL1247352) |
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| Ki | 1300±n/a nM |
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| Citation |  Ishikawa, M; Watanabe, T; Kudo, T; Yokoyama, F; Yamauchi, M; Kato, K; Kakui, N; Sato, Y Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. J Med Chem53:6445-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50326285 |
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| n/a |
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| Name | BDBM50326285 |
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| Synonyms: | (S)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)phenylthio)-ethyl)piperidine | CHEMBL1243394 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20F3N3S |
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| Mol. Mass. | 355.421 |
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| SMILES | FC(F)(F)c1ccc(SC[C@@H](C2CCNCC2)c2cnc[nH]2)cc1 |r| |
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| Structure | 
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