| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50326302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_659960 (CHEMBL1247361) |
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| Ki | 1420±n/a nM |
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| Citation |  Ovat, A; Li, ZZ; Hampton, CY; Asress, SA; Fernández, FM; Glass, JD; Powers, JC Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J Med Chem53:6326-36 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50326302 |
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| n/a |
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| Name | BDBM50326302 |
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| Synonyms: | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(4-methylpiperazin-1-yl)propyl)-2-oxopentanamide | CHEMBL1242987 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H43N5O5 |
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| Mol. Mass. | 517.6608 |
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| SMILES | CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCN(C)CC1 |r| |
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| Structure | 
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