Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMethylthioadenosine Phosphorylase (MTAP)
LigandBDBM50326407
Substrate/Competitorn/a
Meas. Tech.ChEMBL_657428
Ki 3±n/a nM
Citation Longshaw AIAdanitsch FGutierrez JAEvans GBTyler PCSchramm VL Design and synthesis of potent"sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. J Med Chem 53:6730-46 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methylthioadenosine Phosphorylase (MTAP)
Name:Methylthioadenosine Phosphorylase (MTAP)
Synonyms:5'-Methylthioadenosine phosphorylase (MTAP) | MTA phosphorylase | MTAPase | S-methyl-5 -thioadenosine phosphorylase
Type:Enzyme
Mol. Mass.:31239.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326407
n/a
NameBDBM50326407
Synonyms:(+/-)-trans-4-Allyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | CHEMBL1240542
TypeSmall organic molecule
Emp. Form.C14H19N5O
Mol. Mass.273.3336
SMILESNc1ncnc2c(CN3C[C@H](O)[C@@H](CC=C)C3)c[nH]c12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: