| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50326438 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_658036 (CHEMBL1248948) |
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| IC50 | 18±n/a nM |
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| Citation |  Akué-Gédu, R; Nauton, L; Théry, V; Bain, J; Cohen, P; Anizon, F; Moreau, P Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem18:6865-73 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50326438 |
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| n/a |
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| Name | BDBM50326438 |
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| Synonyms: | 9-trifluoromethyl-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL1243129 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H9F3N2O |
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| Mol. Mass. | 302.2507 |
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| SMILES | FC(F)(F)c1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12 |
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| Structure | 
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