| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50326441 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_657899 (CHEMBL1248423) |
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| IC50 | 24±n/a nM |
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| Citation |  Akué-Gédu, R; Nauton, L; Théry, V; Bain, J; Cohen, P; Anizon, F; Moreau, P Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. Bioorg Med Chem18:6865-73 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50326441 |
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| n/a |
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| Name | BDBM50326441 |
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| Synonyms: | 9-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL1241009 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9BrN2O |
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| Mol. Mass. | 313.149 |
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| SMILES | Brc1cccc2c1[nH]c1c2ccc2c(C=O)c[nH]c12 |
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| Structure | 
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