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TargetNADPH oxidase 4
LigandBDBM50326482
Substrate/Competitorn/a
Meas. Tech.ChEMBL_658093
IC50 910±n/a nM
Citation Borbély GSzabadkai IHorváth ZMarkó PVarga ZBreza NBaska FVántus THuszár MGeiszt MHunyady LBuday LOrfi LKéri G Small-molecule inhibitors of NADPH oxidase 4. J Med Chem 53:6758-62 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NADPH oxidase 4
Name:NADPH oxidase 4
Synonyms:KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | RENOX | Renal NAD(P)H-oxidase
Type:PROTEIN
Mol. Mass.:66954.54
Organism:Homo sapiens (Human)
Description:ChEMBL_792879
Residue:578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326482
n/a
NameBDBM50326482
Synonyms:(N'1E,N'2E)-N'1,N'2-bis(2,3-dihydroxybenzylidene)oxalohydrazide | CHEMBL1243187
TypeSmall organic molecule
Emp. Form.C16H14N4O6
Mol. Mass.358.3056
SMILESOc1cccc(C=NNC(=O)C(=O)NN=Cc2cccc(O)c2O)c1O |w:14.13,7.7|
Structure
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