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TargetNADPH oxidase 4
LigandBDBM50240897
Substrate/Competitorn/a
Meas. Tech.ChEMBL_658093
IC50 1020±n/a nM
Citation Borbély GSzabadkai IHorváth ZMarkó PVarga ZBreza NBaska FVántus THuszár MGeiszt MHunyady LBuday LOrfi LKéri G Small-molecule inhibitors of NADPH oxidase 4. J Med Chem 53:6758-62 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NADPH oxidase 4
Name:NADPH oxidase 4
Synonyms:KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | RENOX | Renal NAD(P)H-oxidase
Type:PROTEIN
Mol. Mass.:66954.54
Organism:Homo sapiens (Human)
Description:ChEMBL_792879
Residue:578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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  Blast E-value cutoff:
BDBM50240897
n/a
NameBDBM50240897
Synonyms:2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one | 3',4',5-trihydroxy-3,7-dimethoxyflavone | CHEMBL164861 | Quercetin-3,7-dimethylether
TypeSmall organic molecule
Emp. Form.C17H14O7
Mol. Mass.330.2889
SMILESCOc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(OC)c2=O
Structure
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