| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 4 |
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| Ligand | BDBM50038199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_658093 (CHEMBL1249158) |
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| IC50 | 1340±n/a nM |
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| Citation |  Borbély, G; Szabadkai, I; Horváth, Z; Markó, P; Varga, Z; Breza, N; Baska, F; Vántus, T; Huszár, M; Geiszt, M; Hunyady, L; Buday, L; Orfi, L; Kéri, G Small-molecule inhibitors of NADPH oxidase 4. J Med Chem53:6758-62 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 4 |
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| Name: | NADPH oxidase 4 |
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| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66954.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792879 |
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| Residue: | 578 |
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| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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| BDBM50038199 |
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| n/a |
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| Name | BDBM50038199 |
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| Synonyms: | 5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic acid | 5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid | 5-(N-2',5'-dihydroxybenzyl)aminosalicylic acid | CHEMBL319620 | Lavendustin C |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13NO5 |
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| Mol. Mass. | 275.2567 |
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| SMILES | OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O |
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| Structure | 
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