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TargetD(3) dopamine receptor
LigandBDBM50318666
Substrate/Competitorn/a
Meas. Tech.ChEMBL_658547
IC50>10000±n/a nM
Citation Rottmann MMcNamara CYeung BKLee MCZou BRussell BSeitz PPlouffe DMDharia NVTan JCohen SBSpencer KRGonzález-Páez GELakshminarayana SBGoh ASuwanarusk RJegla TSchmitt EKBeck HPBrun RNosten FRenia LDartois VKeller THFidock DAWinzeler EADiagana TT Spiroindolones, a potent compound class for the treatment of malaria. Science 329:1175-80 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
D(3) dopamine receptor
Name:D(3) dopamine receptor
Synonyms:D2-like dopamine receptor | DOPAMINE D3 | DRD3 | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:n/a
Mol. Mass.:44243.43
Organism:Homo sapiens (Human)
Description:n/a
Residue:400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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  Blast E-value cutoff:
BDBM50318666
n/a
NameBDBM50318666
Synonyms:(1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-tetrahydrospiro-[beta-carboline-1,3'-indol]-2'(1'H)-one | CHEMBL1082723 | NITD609
TypeSmall organic molecule
Emp. Form.C19H14Cl2FN3O
Mol. Mass.390.238
SMILESC[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc21 |r|
Structure
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