Reaction Details |
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Target | Cytochrome c oxidase subunit 2 |
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Ligand | BDBM11639 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_662815 (CHEMBL1252215) |
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IC50 | 60±n/a nM |
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Citation | Zarghi, A; Ghodsi, R Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors. Bioorg Med Chem18:5855-60 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome c oxidase subunit 2 |
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Name: | Cytochrome c oxidase subunit 2 |
Synonyms: | COII | COX2 | COX2_SHEEP | COXII | Cytochrome c oxidase polypeptide II | MT-CO2 | MTCO2 |
Type: | PROTEIN |
Mol. Mass.: | 25987.16 |
Organism: | Ovis aries |
Description: | ChEMBL_662815 |
Residue: | 227 |
Sequence: | MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQE
VETIWTILPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDS
YMIPTSELKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLPSWAVPSLGLKTDAIPGRLN
QTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
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BDBM11639 |
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n/a |
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Name | BDBM11639 |
Synonyms: | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662 |
Type | Small organic molecule |
Emp. Form. | C17H14F3N3O2S |
Mol. Mass. | 381.372 |
SMILES | Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F |
Structure |
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