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TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
LigandBDBM50326989
Substrate/Competitorn/a
Meas. Tech.ChEMBL_663436 (CHEMBL1250984)
EC50 9410±n/a nM
Citation Melchiorre, MDel Lungo, MGuandalini, LMartini, EDei, SManetti, DScapecchi, STeodori, ESartiani, LMugelli, ACerbai, ERomanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Synonyms:BCNG-1 | Bcng1 | Brain cyclic nucleotide-gated channel 1 | HAC-2 | HCN1_MOUSE | Hac2 | Hcn1 | Hyperpolarization-activated cation channel 2
Type:PROTEIN
Mol. Mass.:102447.84
Organism:Mus musculus
Description:ChEMBL_663436
Residue:910
Sequence:
MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDG
GGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAG
FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLI
MNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTA
RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHW
DGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSD
LWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKI
HDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKL
RFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTA
SVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNT
GVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTAT
SLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQ
QPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPG
SSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPV
AAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPD
AEKPRFASNL
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  Blast E-value cutoff:
BDBM50326989
n/a
NameBDBM50326989
Synonyms:3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253992
TypeSmall organic molecule
Emp. Form.C28H36N2O5
Mol. Mass.480.5958
SMILESCOc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21|
Structure
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