Reaction Details |
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Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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Ligand | BDBM50326991 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_663438 (CHEMBL1250986) |
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EC50 | 17220±n/a nM |
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Citation | Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
Synonyms: | BCNG-2 | Bcng2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | HCN2_MOUSE | Hac1 | Hcn2 | Hyperpolarization-activated cation channel 1 |
Type: | PROTEIN |
Mol. Mass.: | 94741.48 |
Organism: | Mus musculus |
Description: | ChEMBL_663438 |
Residue: | 863 |
Sequence: | MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRA
RLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSE
EAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY
SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGI
VIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVR
FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFL
VPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS
MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR
YQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQP
GDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTY
CRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQE
NAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVG
PLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPAL
PARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDS
ASPGAASGLDPLDSARSRLSSNL
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BDBM50326991 |
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n/a |
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Name | BDBM50326991 |
Synonyms: | 3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253993 |
Type | Small organic molecule |
Emp. Form. | C27H34N2O5 |
Mol. Mass. | 466.5693 |
SMILES | COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15| |
Structure |
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