Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
LigandBDBM50326991
Substrate/Competitorn/a
Meas. Tech.ChEMBL_663438 (CHEMBL1250986)
EC50 17220±n/a nM
Citation Melchiorre, MDel Lungo, MGuandalini, LMartini, EDei, SManetti, DScapecchi, STeodori, ESartiani, LMugelli, ACerbai, ERomanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Name:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms:BCNG-2 | Bcng2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | HCN2_MOUSE | Hac1 | Hcn2 | Hyperpolarization-activated cation channel 1
Type:PROTEIN
Mol. Mass.:94741.48
Organism:Mus musculus
Description:ChEMBL_663438
Residue:863
Sequence:
MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRA
RLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSE
EAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY
SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGI
VIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVR
FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFL
VPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS
MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR
YQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQP
GDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTY
CRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQE
NAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVG
PLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPAL
PARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDS
ASPGAASGLDPLDSARSRLSSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326991
n/a
NameBDBM50326991
Synonyms:3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253993
TypeSmall organic molecule
Emp. Form.C27H34N2O5
Mol. Mass.466.5693
SMILESCOc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: