| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Ligand | BDBM50326992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_663438 (CHEMBL1250986) |
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| EC50 | 4520±n/a nM |
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| Citation |  Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem53:6773-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Synonyms: | BCNG-2 | Bcng2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | HCN2_MOUSE | Hac1 | Hcn2 | Hyperpolarization-activated cation channel 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94741.48 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_663438 |
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| Residue: | 863 |
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| Sequence: | MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRA
RLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSE
EAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPY
SDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGI
VIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVR
FTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFL
VPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS
MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR
YQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQP
GDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTY
CRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQE
NAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVG
PLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPAL
PARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDS
ASPGAASGLDPLDSARSRLSSNL
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| BDBM50326992 |
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| n/a |
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| Name | BDBM50326992 |
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| Synonyms: | CHEMBL471737 | ivabradine |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N2O5 |
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| Mol. Mass. | 468.5851 |
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| SMILES | COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC |r| |
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| Structure | 
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