| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
|---|
| Ligand | BDBM50327044 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_663732 (CHEMBL1250632) |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  Barney, RJ; Wasko, BM; Dudakovic, A; Hohl, RJ; Wiemer, DF Synthesis and biological evaluation of a series of aromatic bisphosphonates. Bioorg Med Chem18:7212-20 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Geranylgeranyl pyrophosphate synthase |
|---|
| Name: | Geranylgeranyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
|---|
| Type: | Homooctamer; transferase |
|---|
| Mol. Mass.: | 34867.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
|---|
| Residue: | 300 |
|---|
| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
|
|
|---|
| BDBM50327044 |
|---|
| n/a |
|---|
| Name | BDBM50327044 |
|---|
| Synonyms: | CHEMBL1254000 | sodium(E)-5,9-dimethyl-1-(3-(3-methylbut-2-enyl)phenyl)deca-4,8-diene-2,2-diyldiphosphonate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H32O6P2 |
|---|
| Mol. Mass. | 466.4463 |
|---|
| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]C([#6]-c1cccc(-[#6]\[#6]=[#6](\[#6])-[#6])c1)(P([#8-])([#8-])=O)P([#8-])([#8-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
