| Reaction Details |
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 | Report a problem with these data |
| Target | Myelin-associated glycoprotein |
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| Ligand | BDBM50327099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_663794 (CHEMBL1250694) |
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| Kd | 500±n/a nM |
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| Citation |  Schwardt, O; Koliwer-Brandl, H; Zimmerli, R; Mesch, S; Rossato, G; Spreafico, M; Vedani, A; Kelm, S; Ernst, B Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein. Bioorg Med Chem18:7239-51 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Myelin-associated glycoprotein |
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| Name: | Myelin-associated glycoprotein |
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| Synonyms: | MAG_MOUSE | Mag | Siglec-4a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69368.91 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_663794 |
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| Residue: | 627 |
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| Sequence: | MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWY
FNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGD
LGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGL
GEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPP
VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGED
GVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIF
KEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESH
CAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQA
QAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKK
NVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKQRLGSERRLLGLRGESPELDLSYSH
SDLGKRPTKDSYTLTEELAEYAEIRVK
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| BDBM50327099 |
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| n/a |
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| Name | BDBM50327099 |
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| Synonyms: | CHEMBL1253679 | sodium2R,4S,5R,6R)-6-((1R,2R)-3-(4-chlorobenzamido)-1,2-dihydroxypropyl)-2-(2,3-difluorobenzyloxy)-5-(2-fluoroacetamido)-4-hydroxytetrahydro-2H-pyran-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClF3N2O9 |
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| Mol. Mass. | 589.923 |
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| SMILES | O[C@H](CNC(=O)c1ccc(Cl)cc1)[C@@H](O)[C@@H]1O[C@@](C[C@H](O)[C@H]1NC(=O)CF)(OCc1cccc(F)c1F)C([O-])=O |r| |
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| Structure | 
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