Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50327245 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_664323 (CHEMBL1259358) |
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IC50 | 22049±n/a nM |
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Citation | Brugel, TA; Smith, RW; Balestra, M; Becker, C; Daniels, T; Hoerter, TN; Koether, GM; Throner, SR; Panko, LM; Folmer, JJ; Cacciola, J; Hunter, AM; Liu, R; Edwards, PD; Brown, DG; Gordon, J; Ledonne, NC; Pietras, M; Schroeder, P; Sygowski, LA; Hirata, LT; Zacco, A; Peters, MF Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. Bioorg Med Chem Lett20:5847-52 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50327245 |
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n/a |
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Name | BDBM50327245 |
Synonyms: | CHEMBL1255595 | endo-3-(8-((5-methylfuran-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide |
Type | Small organic molecule |
Emp. Form. | C20H24N2O3 |
Mol. Mass. | 340.4162 |
SMILES | Cc1ccc(CN2[C@H]3CC[C@@H]2C[C@H](C3)Oc2cccc(c2)C(N)=O)o1 |r,TLB:5:6:12.11.13:9.8| |
Structure |
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