| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50327245 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664322 (CHEMBL1259357) |
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| IC50 | 10854±n/a nM |
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| Citation |  Brugel, TA; Smith, RW; Balestra, M; Becker, C; Daniels, T; Hoerter, TN; Koether, GM; Throner, SR; Panko, LM; Folmer, JJ; Cacciola, J; Hunter, AM; Liu, R; Edwards, PD; Brown, DG; Gordon, J; Ledonne, NC; Pietras, M; Schroeder, P; Sygowski, LA; Hirata, LT; Zacco, A; Peters, MF Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. Bioorg Med Chem Lett20:5847-52 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44789.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35372 |
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| Residue: | 400 |
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| Sequence: | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50327245 |
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| n/a |
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| Name | BDBM50327245 |
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| Synonyms: | CHEMBL1255595 | endo-3-(8-((5-methylfuran-2-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O3 |
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| Mol. Mass. | 340.4162 |
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| SMILES | Cc1ccc(CN2[C@H]3CC[C@@H]2C[C@H](C3)Oc2cccc(c2)C(N)=O)o1 |r,TLB:5:6:12.11.13:9.8| |
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| Structure | 
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