Reaction Details |
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Target | LIM domain kinase 2 |
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Ligand | BDBM50327391 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_664472 (CHEMBL1259854) |
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IC50 | 3.05±n/a nM |
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Citation | Lin, S; Wrobleski, ST; Hynes, J; Pitt, S; Zhang, R; Fan, Y; Doweyko, AM; Kish, KF; Sack, JS; Malley, MF; Kiefer, SE; Newitt, JA; McKinnon, M; Trzaskos, J; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38a MAP kinase inhibitors. Bioorg Med Chem Lett20:5864-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 2 |
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Name: | LIM domain kinase 2 |
Synonyms: | LIMK2 | LIMK2_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 72238.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1514398 |
Residue: | 638 |
Sequence: | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
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BDBM50327391 |
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n/a |
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Name | BDBM50327391 |
Synonyms: | CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol-5-yl)pyrimidin-2-yl)-N2,N2-dimethylethane-1,2-diamine |
Type | Small organic molecule |
Emp. Form. | C20H25ClN6S |
Mol. Mass. | 416.971 |
SMILES | CC(C)Nc1ncc(s1)-c1cc(nc(NCCN(C)C)n1)-c1ccccc1Cl |
Structure |
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