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TargetMitogen-activated protein kinase 14
LigandBDBM50327417
Substrate/Competitorn/a
Meas. Tech.ChEMBL_664469 (CHEMBL1259851)
IC50 7±n/a nM
Citation Lin, SWrobleski, STHynes, JPitt, SZhang, RFan, YDoweyko, AMKish, KFSack, JSMalley, MFKiefer, SENewitt, JAMcKinnon, MTrzaskos, JBarrish, JCDodd, JHSchieven, GLLeftheris, K Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38a MAP kinase inhibitors. Bioorg Med Chem Lett20:5864-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50327417
n/a
NameBDBM50327417
Synonyms:1-(2-(2-(2-(dimethylamino)ethylamino)-6-(2-(isopropylamino)thiazol-5-yl)pyrimidin-4-yl)benzyl)-3-ethylurea | 1-[2-(2-{[2-(dimethylamino)ethyl]amino}-6-{2-[(1-methylethyl)amino]-1,3-thiazol-5-yl}pyrimidin-4-yl)benzyl]-3-ethylurea | CHEMBL1230171
TypeSmall organic molecule
Emp. Form.C24H34N8OS
Mol. Mass.482.645
SMILESCCNC(=O)NCc1ccccc1-c1cc(nc(NCCN(C)C)n1)-c1cnc(NC(C)C)s1
Structure
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