| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50327854 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664906 (CHEMBL1259738) |
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| IC50 | 0.7±n/a nM |
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| Citation |  Rose, TE; Morisseau, C; Liu, JY; Inceoglu, B; Jones, PD; Sanborn, JR; Hammock, BD 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem53:7067-75 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62512.06 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P34914 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
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| BDBM50327854 |
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| n/a |
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| Name | BDBM50327854 |
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| Synonyms: | 1-(1-(6-Chloronicotinoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL1257170 | US9296693, 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClF3N4O3 |
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| Mol. Mass. | 442.819 |
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| SMILES | FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)C(=O)c2ccc(Cl)nc2)cc1 |
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| Structure | 
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