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Target5-hydroxytryptamine receptor 4
LigandBDBM50327863
Substrate/Competitorn/a
Meas. Tech.ChEMBL_664907 (CHEMBL1259739)
Ki 0.334000±n/a nM
Citation Xu, RHong, JMorse, CLPike, VW Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. J Med Chem53:7035-47 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 4
Name:5-hydroxytryptamine receptor 4
Synonyms:5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43735.29
Organism:GUINEA PIG
Description:5-HT4 HTR4 GUINEA PIG::O70528
Residue:388
Sequence:
MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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BDBM50327863
n/a
NameBDBM50327863
Synonyms:(1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate | CHEMBL1258671
TypeSmall organic molecule
Emp. Form.C19H27FN2O4
Mol. Mass.366.4271
SMILESCCCCN1CCC(COC(=O)c2cc(F)c(N)c3OCCOc23)CC1
Structure
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