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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase mTOR | ||
| Ligand | BDBM50327905 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_665023 (CHEMBL1260133) | ||
| Ki | 6.8±n/a nM | ||
| Citation |  Liu, KK; Bagrodia, S; Bailey, S; Cheng, H; Chen, H; Gao, L; Greasley, S; Hoffman, JE; Hu, Q; Johnson, TO; Knighton, D; Liu, Z; Marx, MA; Nambu, MD; Ninkovic, S; Pascual, B; Rafidi, K; Rodgers, CM; Smith, GL; Sun, S; Wang, H; Yang, A; Yuan, J; Zou, A 4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors. Bioorg Med Chem Lett20:6096-9 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase mTOR | |||
| Name: | Serine/threonine-protein kinase mTOR | ||
| Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
| Type: | Rapamycin target protein | ||
| Mol. Mass.: | 288917.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42345 | ||
| Residue: | 2549 | ||
| Sequence: |
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| BDBM50327905 | |||
| n/a | |||
| Name | BDBM50327905 | ||
| Synonyms: | CHEMBL1257177 | trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpteridin-7(8H)-one | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H22N6O3 | ||
| Mol. Mass. | 382.4164 | ||
| SMILES | COc1ccc(cn1)-c1nc2c(C)nc(N)nc2n([C@H]2CC[C@H](O)CC2)c1=O |r,wU:19.20,wD:22.24,(6.1,-15.1,;4.76,-14.34,;3.43,-15.12,;3.44,-16.66,;2.11,-17.44,;.77,-16.67,;.76,-15.14,;2.09,-14.36,;-.55,-17.45,;-1.88,-16.69,;-3.21,-17.46,;-4.55,-16.7,;-4.55,-15.16,;-5.87,-17.47,;-5.88,-19.01,;-7.21,-19.78,;-4.54,-19.78,;-3.21,-19,;-1.87,-19.77,;-1.87,-21.31,;-.53,-22.08,;-.54,-23.62,;-1.87,-24.39,;-1.87,-25.93,;-3.2,-23.62,;-3.2,-22.08,;-.54,-19,;.8,-19.76,)| | ||
| Structure | 
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