| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM50327912 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_665089 (CHEMBL1260199) |
|---|
| IC50 | 45±n/a nM |
|---|
| Citation |  Bindi, S; Fancelli, D; Alli, C; Berta, D; Bertrand, JA; Cameron, AD; Cappella, P; Carpinelli, P; Cervi, G; Croci, V; D'Anello, M; Forte, B; Giorgini, ML; Marsiglio, A; Moll, J; Pesenti, E; Pittalà, V; Pulici, M; Riccardi-Sirtori, F; Roletto, F; Soncini, C; Storici, P; Varasi, M; Volpi, D; Zugnoni, P; Vianello, P Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity. Bioorg Med Chem18:7113-20 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM50327912 |
|---|
| n/a |
|---|
| Name | BDBM50327912 |
|---|
| Synonyms: | 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]pyrazole-5-carboxylic acid((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-amide | CHEMBL1258913 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32N6O3S |
|---|
| Mol. Mass. | 544.668 |
|---|
| SMILES | O=C(N[C@H](CN1CCCC1)c1ccccc1)c1cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCOCC3)c2s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
