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TargetMalonyl-CoA decarboxylase, mitochondrial
LigandBDBM50328220
Substrate/Competitorn/a
Meas. Tech.ChEMBL_665404 (CHEMBL1261133)
IC50 3.2±n/a nM
Citation Tang, HYan, YFeng, Zde Jesus, RKYang, LLevorse, DAOwens, KAAkiyama, TEBergeron, RCastriota, GADoebber, TWEllsworth, KPLassman, MELi, CWu, MSZhang, BBChapman, KTMills, SGBerger, JPPasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett20:6088-92 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malonyl-CoA decarboxylase, mitochondrial
Name:Malonyl-CoA decarboxylase, mitochondrial
Synonyms:DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:PROTEIN
Mol. Mass.:55018.37
Organism:Homo sapiens (Human)
Description:ChEMBL_665404
Residue:493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50328220
n/a
NameBDBM50328220
Synonyms:2-(2-(4-(3-aminophenyl)piperazin-1-yl)thiazol-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol | CHEMBL1258590
TypeSmall organic molecule
Emp. Form.C16H16F6N4OS
Mol. Mass.426.38
SMILESNc1cccc(c1)N1CCN(CC1)c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F
Structure
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