| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
|---|
| Ligand | BDBM50328450 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_665574 (CHEMBL1261458) |
|---|
| Ki | 210±n/a nM |
|---|
| Citation |  Skultety, M; Hübner, H; Löber, S; Gmeiner, P Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. J Med Chem53:7219-28 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(1A) dopamine receptor |
|---|
| Name: | D(1A) dopamine receptor |
|---|
| Synonyms: | DRD1 | DRD1_PIG | Dopamine D1 receptor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49269.92 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_1460140 |
|---|
| Residue: | 446 |
|---|
| Sequence: | MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLG
KTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIET
VSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
|
|
|
|---|
| BDBM50328450 |
|---|
| n/a |
|---|
| Name | BDBM50328450 |
|---|
| Synonyms: | 4-[4-(2,5-Dimethylphenyl)piperazin-1-yl]-1-(4-fluorophenyl)-butan-1-one | CHEMBL1258037 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27FN2O |
|---|
| Mol. Mass. | 354.461 |
|---|
| SMILES | Cc1ccc(C)c(c1)N1CCN(CCCC(=O)c2ccc(F)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
