| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50328678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_672864 (CHEMBL1267839) |
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| IC50 | 300±n/a nM |
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| Citation |  Hutt, DM; Herman, D; Rodrigues, AP; Noel, S; Pilewski, JM; Matteson, J; Hoch, B; Kellner, W; Kelly, JW; Schmidt, A; Thomas, PJ; Matsumura, Y; Skach, WR; Gentzsch, M; Riordan, JR; Sorscher, EJ; Okiyoneda, T; Yates, JR; Lukacs, GL; Frizzell, RA; Manning, G; Gottesfeld, JM; Balch, WE Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol6:25-33 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50328678 |
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| n/a |
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| Name | BDBM50328678 |
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| Synonyms: | 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide | 6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanamide | CHEMBL96051 | GNF-Pf-2024 | Scriptaid | Scriptaid, 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O4 |
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| Mol. Mass. | 326.3465 |
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| SMILES | ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23 |
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| Structure | 
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