Reaction Details |
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Target | Protein arginine N-methyltransferase 1 [11-371] |
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Ligand | BDBM50328754 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_675342 (CHEMBL1273379) |
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IC50 | 867400±n/a nM |
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Citation | Feng, Y; Li, M; Wang, B; Zheng, YG Discovery and mechanistic study of a class of protein arginine methylation inhibitors. J Med Chem53:6028-39 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 1 [11-371] |
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Name: | Protein arginine N-methyltransferase 1 [11-371] |
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
Type: | Protein |
Mol. Mass.: | 41506.52 |
Organism: | Homo sapiens (Human) |
Description: | Q99873[11-371] |
Residue: | 361 |
Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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BDBM50328754 |
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n/a |
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Name | BDBM50328754 |
Synonyms: | 8-(p-tolylamino)naphthalene-1-sulfonamide | CHEMBL1269944 |
Type | Small organic molecule |
Emp. Form. | C17H16N2O2S |
Mol. Mass. | 312.386 |
SMILES | Cc1ccc(Nc2cccc3cccc(c23)S(N)(=O)=O)cc1 |
Structure |
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