Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50328774 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_673596 (CHEMBL1274709) |
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IC50 | 10±n/a nM |
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Citation | Ahn, YM; Clare, M; Ensinger, CL; Hood, MM; Lord, JW; Lu, WP; Miller, DF; Patt, WC; Smith, BD; Vogeti, L; Kaufman, MD; Petillo, PA; Wise, SC; Abendroth, J; Chun, L; Clark, R; Feese, M; Kim, H; Stewart, L; Flynn, DL Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region. Bioorg Med Chem Lett20:5793-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50328774 |
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n/a |
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Name | BDBM50328774 |
Synonyms: | 2-(3-(3-cyclopentyl-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)phenyl)acetamide | CHEMBL1269947 |
Type | Small organic molecule |
Emp. Form. | C23H23Cl2N5O2 |
Mol. Mass. | 472.367 |
SMILES | NC(=O)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1cccc(Cl)c1Cl)C1CCCC1 |
Structure |
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