| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50328807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_673777 (CHEMBL1274954) |
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| IC50 | 2±n/a nM |
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| Citation |  Anderson, JT; Campbell, M; Wang, J; Brunden, KR; Harrington, JJ; Stricker-Krongrad, A; Song, J; Doucette, C; Murphy, S; Bennani, YL Investigation of 4-piperidinols as novel H3 antagonists. Bioorg Med Chem Lett20:6246-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50328807 |
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| n/a |
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| Name | BDBM50328807 |
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| Synonyms: | (2R,4S,5S)-1,2,5-trimethyl-4-(2-(naphthalen-1-yl)ethyl)piperidin-4-ol | CHEMBL1270059 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27NO |
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| Mol. Mass. | 297.4345 |
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| SMILES | C[C@@H]1C[C@@](O)(CCc2cccc3ccccc23)[C@@H](C)CN1C |r| |
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| Structure | 
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