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TargetRenin
LigandBDBM50328871
Substrate/Competitorn/a
Meas. Tech.ChEMBL_673945 (CHEMBL1275122)
IC50 2.80±n/a nM
Citation Corminboeuf, OBezençon, OGrisostomi, CRemen, LRichard-Bildstein, SBur, DPrade, LHess, PStrickner, PFischli, WSteiner, BTreiber, A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett20:6286-90 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50328871
n/a
NameBDBM50328871
Synonyms:(3R,4S)-N-(2-chloro-5-(cyclopropanecarboxamidomethyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamide | CHEMBL1269691
TypeSmall organic molecule
Emp. Form.C36H40Cl3N3O4
Mol. Mass.685.08
SMILESCc1cc(Cl)c(OCCOc2ccc(cc2)[C@H]2CCNC[C@@H]2C(=O)N(Cc2cc(CNC(=O)C3CC3)ccc2Cl)C2CC2)c(Cl)c1 |r|
Structure
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