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TargetRenin
LigandBDBM50328866
Substrate/Competitorn/a
Meas. Tech.ChEMBL_673944
IC50 0.18±n/a nM
Citation Corminboeuf OBezençon OGrisostomi CRemen LRichard-Bildstein SBur DPrade LHess PStrickner PFischli WSteiner BTreiber A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett 20:6286-90 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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  Blast E-value cutoff:
BDBM50328866
n/a
NameBDBM50328866
Synonyms:CHEMBL1270761 | rac-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(2,3-dimethylbenzyl)-4-hydroxypiperidine-3-carboxamide
TypeSmall organic molecule
Emp. Form.C33H38Cl2N2O4
Mol. Mass.597.572
SMILESCc1cc(Cl)c(OCCOc2ccc(cc2)C2(O)CCNCC2C(=O)N(Cc2cccc(C)c2C)C2CC2)c(Cl)c1
Structure
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